{"id":5869,"date":"2019-10-03T15:35:47","date_gmt":"2019-10-03T08:35:47","guid":{"rendered":"http:\/\/huib.hueuni.edu.vn\/?p=5869"},"modified":"2019-10-03T15:35:47","modified_gmt":"2019-10-03T08:35:47","slug":"pocket-size-nanopore-device-sequences-entire-human-genome","status":"publish","type":"post","link":"https:\/\/huib.hueuni.edu.vn\/en\/pocket-size-nanopore-device-sequences-entire-human-genome\/","title":{"rendered":"Pocket-Size Nanopore Device Sequences Entire Human Genome"},"content":{"rendered":"<p style=\"background: white; text-align: justify;\">Researchers have assembled the entire human genome using a nanopore sequencer, according to a study published today (January 29) in\u00a0<a href=\"https:\/\/www.nature.com\/articles\/nbt.4060\"><em><span style=\"color: windowtext; text-decoration: none; text-underline: none;\">Nature Biotechnology<\/span><\/em><\/a>. Using a pocket-size device, dubbed MinION, the team was able to fill 12 gaps in the sequenced human genome by achieving reads of DNA sequences nearly one million bases in length\u2014the longest to date.<\/p>\n<p style=\"background: white; text-align: justify;\">\u201cWe&#8217;ve gone from a situation where you can only do genome sequencing for a huge amount of money in well-equipped labs to one where we can have genome sequencing literally in your pocket just like a mobile phone,\u201d study coauthor Nicholas Loman, a bioinformatician from the University of Birmingham, tells the\u00a0<a href=\"http:\/\/www.bbc.com\/news\/health-42838821\"><em><span style=\"color: windowtext; text-decoration: none; text-underline: none;\">BBC<\/span><\/em><\/a>. \u201cThat gives us a really exciting opportunity to start having genome sequencing as a routine tool, perhaps something people can do in their own home.\u201d<\/p>\n<p style=\"background: white; text-align: justify;\">The study involved 26 investigations in five separate labs, including some at the National Institutes of Health. Using MinION, researchers generated ultra-long DNA reads that were up to 882,000 bases long\u2014more than twice the length of what had been previously achieved. Last week, they reached lengths of \u201c1.3 million bases,\u201d study coauthor Matt Loose, a geneticist at the University of Nottingham, tells\u00a0<a href=\"https:\/\/www.statnews.com\/2018\/01\/29\/hand-held-dna-sequencer-minion\/\"><em><span style=\"color: windowtext; text-decoration: none; text-underline: none;\">STAT News<\/span><\/em><\/a><em>.<\/em><\/p>\n<p style=\"background: white; text-align: justify;\">\u201cThe main innovation here, in my opinion, is the ultra-long reads,\u201d Mick Watson, a computational biologist at the University of Edinburgh who was not involved in the study, tells\u00a0<em>STAT News<\/em>. \u201cThose guys report reads more than 1 million bases in length, which is amazing and something that really separates Oxford\u2019s technology from anyone else\u2019s.\u201d<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-5866\" src=\"http:\/\/huib.hueuni.edu.vn\/wp-content\/uploads\/2019\/10\/cb36c564-7772-4c0e-b956-7a77587c31e8-minion640.jpg\" alt=\"\" width=\"640\" height=\"360\" srcset=\"https:\/\/huib.hueuni.edu.vn\/wp-content\/uploads\/2019\/10\/cb36c564-7772-4c0e-b956-7a77587c31e8-minion640.jpg 640w, https:\/\/huib.hueuni.edu.vn\/wp-content\/uploads\/2019\/10\/cb36c564-7772-4c0e-b956-7a77587c31e8-minion640-300x169.jpg 300w, https:\/\/huib.hueuni.edu.vn\/wp-content\/uploads\/2019\/10\/cb36c564-7772-4c0e-b956-7a77587c31e8-minion640-260x146.jpg 260w, https:\/\/huib.hueuni.edu.vn\/wp-content\/uploads\/2019\/10\/cb36c564-7772-4c0e-b956-7a77587c31e8-minion640-50x28.jpg 50w, https:\/\/huib.hueuni.edu.vn\/wp-content\/uploads\/2019\/10\/cb36c564-7772-4c0e-b956-7a77587c31e8-minion640-133x75.jpg 133w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<p style=\"text-align: center;\"><em>The MinION nanopore sequencer<\/em><\/p>\n<p style=\"text-align: right;\"><em>Original published by The Scientist<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have assembled the entire human genome using a nanopore sequencer, according to a study published today (January<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":3,"featured_media":5866,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[67],"tags":[163,162],"class_list":["post-5869","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-technology","tag-hue-university","tag-institute-of-biotechnology"],"_links":{"self":[{"href":"https:\/\/huib.hueuni.edu.vn\/en\/wp-json\/wp\/v2\/posts\/5869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/huib.hueuni.edu.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/huib.hueuni.edu.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/huib.hueuni.edu.vn\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/huib.hueuni.edu.vn\/en\/wp-json\/wp\/v2\/comments?post=5869"}],"version-history":[{"count":0,"href":"https:\/\/huib.hueuni.edu.vn\/en\/wp-json\/wp\/v2\/posts\/5869\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/huib.hueuni.edu.vn\/en\/wp-json\/wp\/v2\/media\/5866"}],"wp:attachment":[{"href":"https:\/\/huib.hueuni.edu.vn\/en\/wp-json\/wp\/v2\/media?parent=5869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/huib.hueuni.edu.vn\/en\/wp-json\/wp\/v2\/categories?post=5869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/huib.hueuni.edu.vn\/en\/wp-json\/wp\/v2\/tags?post=5869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}